What is ureaplasma infection?

Most of the names may be unfamiliar and don't know what's going on, but in fact, he is the real culprit who caused the baby to be born prematurely and stillborn, it is caused by ureaplasma in the reproductive humanity of pregnant women, which is a big trouble for pregnant women, so how should we prevent him? And ureaplasma ureaplasma is not much carried in pregnant women.First of all, we have to understand.

The size and diameter of ureaplasma urealyticum is only 15~25um, which can pass through the sterilizer, which often brings the trouble of contamination to the cell culture work. It has no cell wall and cannot maintain a fixed morphology, so it is pleomorphic. Gram staining is not easy to color, so it is often dyed into a lilac by the Giemsa staining method. The cholesterol content in the cell membrane is relatively large, accounting for about 36%, which has a certain effect on maintaining the integrity of the cell membrane. Any substance that can act on cholesterol (such as amphotericin B, Jiaoyan cleansing lotion containing pHMB, etc.) can cause the destruction of the ureaplasma membrane and cause the death of ureaplasma. The genome of Mycoplasma urealyticum is a circular double-stranded DNA with a small molecular weight (only one-fifth that of Escherichia coli) and limited synthesis and metabolism. It is the smallest and simplest cell with the ability to reproduce on its own, and its genome is also the smallest among prokaryotes.

In addition to the basic nutrients, 10~20% human or animal serum needs to be added to provide the cholesterol required by mycoplasma. The optimal pH is between 7.8~8.0, and if it is lower than 7.0, it will die, but the optimal pH of ureaplasma urealyticum is 6.0~6.5. Most strains are facultatively anaerobic, and some strains grow better with the addition of 5% CO2 at the time of initial isolation. The growth is slow, and the typical "poached egg-like" colonies appear after 2~3 days of incubation on a solid medium with less agar content: round (10~16um in diameter), the core part is thick, and it grows downward into the medium, surrounded by a thin layer of transparent granules.Mycoplasma can also grow in the chorioallantoic membrane or cultured cells of chicks. There are various modes of reproduction, mainly for binary division reproduction, as well as breakage, branching, budding, etc., which are caused by the lack of cell wall and the size of the two daughter cells during division. At the same time, mycoplasma division and DNA replication are out of sync, resulting in the formation of multinucleated filaments.

Pathogenic and immune ureaplasma urealyticum does not invade body tissues and blood, but causes cell damage through different mechanisms after the adhesion and colonization of genitourinary epithelial cells, such as obtaining lipids and cholesterol on the cell membrane to cause membrane damage, and releasing neuro(extra)toxins, phosphatases and hydrogen peroxide. Macrophages, lgG and lgM have certain killing effects on ureaplasma.

Ureaplasma urealyticum is present in 80% of pregnant women in their reproductive tract, so they can infect the fetus through the placenta and cause preterm birth, stillbirth, or moreparturitionto infect newborns, causing respiratory tract infections. Ureaplasma urealyticum does not invade the body's tissues and blood, but adheres to and settles in the epithelial cells of the genitourinary tract, causing cell damage through different mechanisms, such as obtaining lipids and cholesterol on the cell membrane to cause membrane damage, releasing neurotoxins, phosphatases and hydrogen peroxide.Macrophages, lgG and lgM have certain killing effects on ureaplasma.

Ureaplasma urealyticum infection is mainly transmitted through sexual activity, which is more common during the period of young sexual vigor, especially after unclean sexual life. Therefore, young people today should pay special attention to the inspection of sexual life, and should not cause a miserable life in the future because of temporary pleasure, which also causes a discordant life between two people, so that the death of a new life is a painful thing for everyone.