What is the dosage of etoerythromycin suspension for mycoplasma pneumonia?

Etoerythromycin suspension (Yibaoyuan) is a prescription drug, which is developed and produced by Consun Pharmaceutical (Inner Mongolia) Co., Ltd., which is effective for (1) mycoplasma pneumonia; (2) Neonatal conjunctivitis and infantile pneumonia caused by Chlamydia trachomatis; (3) genitourinary tract infections (including non-gonorrhea urethritis); (4) Legionnaires' disease; (5) Diphtheria (adjuvant therapy) and diphtheria carriers; (6) skin and soft tissue infection; (7) Pertussis, etc.There are good results. So what is the dosage of etoriosthromycin suspension for mycoplasma pneumonia?

Etoerythromycin suspension has a certain amount (about 33% of the blood concentration) into the prostate and seminal vesicles, but it is not easy to penetrate the blood-cerebrospinal fluid barrier, and the concentration in the cerebrospinal fluid is only about 10% of the blood concentration when the meninges are inflamed. Etoerythromycin suspension can enter the fetal blood and be discharged into breast milk, the fetal blood concentration is 5% ~ 20% of the maternal blood concentration, and the drug concentration in breast milk can reach more than 50% of the blood concentration. The apparent volume of distribution (Vd) is 0.9L/kg. The free erythromycin in etoerythromycin suspension is metabolized in the liver, and the blood elimination half-life (T1/2a) of etoerythromycin suspension is 1.4~2 hours, and the blood half-life of anuria patients can be extended to 4.8~6 hours. Etoerythromycin suspension is mainly concentrated in the liver and excreted from bile, and enterohepatic circulation, etoerythromycin suspension about 2%~5% of the oral amount and 10%~15% of the injection amount are eliminated from glomerular filtration, and the concentration in urine can reach 10~100mg/L. There is also a certain amount in the stool. Blood or peritoneal membranes based on erythromycin suspension are rarely cleared after dialysis and do not need to be added after dialysis.

Etoerythromycin suspension is quickly absorbed on an empty stomach or orally after meals, and etoerythromycin suspension is more stable in gastric acid. The protein binding rate of etoerythromycin suspension is 90%~99%. Etoerythromycin suspension is decomposed into erythromycin propionate in the gastrointestinal tract after oral administration, and part of it is hydrolyzed into free erythromycin in the blood and plays an antibacterial role. The peak plasma concentrations (Cmax) of etoerythromycin suspension were reached at 2 hours at 0.25 g and 0.5 g, respectively, at 1.4 mg/L and 4.2 mg/L, respectively.In addition to cerebrospinal fluid and brain tissue, the concentration of erythromycin suspension is widely distributed in various tissues and body fluids, especially in the liver, bile and spleen, and the concentration of erythromycin suspension in kidney, lung and other tissues can be several times higher than the concentration of hemorrhagic drugs, and the concentration in bile can reach more than 10~40 times of the blood concentration. The concentration of etoerythromycin suspension in subcutaneous tissues, sputum and bronchial secretions is also high, and the concentration in sputum is similar to that of blood drugs; Concentrations in the chest, ascites, pus, etc., can reach effective levels.

Dosage of etoerythromycin suspension for mycoplasma pneumonia: oral, children should be taken 30~50mg/kg according to body weight every day, divided into 3~4 times.