What is the cause of Mycoplasma uroplasma infection

We all know that the appearance of any disease has a cause, and it does not appear for no reason. But in life, we often don't know the cause of the disease. Mycoplasma uroplasma infection is a relatively serious disease in life, and many people are very worried about the treatment of this disease. But what is more critical than treatment is that we first understand the cause of the disease. So what exactly is the cause of Mycoplasma uroplasma infection? Let's take a look at how the editor answers this question.

(1) The cause of the disease

In 1937, Drsnes et al. isolated mycoplasma from Bartholey's gland abscess, which was the first reported case of mycoplasma pathogenic in humans.There are as many as 7 types of mycoplasma detected from the genitourinary tract, mainly M. hominis (MH) and ureaplasmaurealyticum (UU). The pathogenicity of mycoplasma is generally not considered to be important in the pathogenesis of NGU. The study of the etiology of UU as NGU has the following aspects.

1. Isolation and culture of UU in nearly 50%~60% of NGU patients (with or without Chlamydia trachomatis). The detection rate of UU in the urethra of chlamydia trachomatis negative NGU patients was significantly higher than that of chlamydia-positive NGU patients or non-NGU control groups.

2. Antibiotic treatment trial sulfonamides and rifampicin are effective against chlamydia and not against UU. Whereas, spectinomycin and streptomycin are effective against UU and not against chlamydia. Patients with urethritis who have negative chlamydia culture but positive UU culture have poor efficacy against sulfonamides and rifampicin, but when treated with spectinomycin or streptomycin, the clinical symptoms improve if the UU is cleared, and there is no clinical improvement if the UU is not cleared.

3. Urethritis and transient serum antibody reactions occurred after primate inoculation with UU in the human urethra, and minocycline (dimethylaminetetracycline) treatment was effective, indicating that some mycoplasma are pathogenic under natural conditions. Inoculation of UU into the urethra of non-human primates allowed for the isolation of mycoplasma, and neutrophils were elevated on urethral swab smears.

(2) Pathogenesis

The pathogenesis of the disease is unknown. Serotype studies have found that there are at least 14 serotypes of UU, and serotype 4 is the most common UU isolated from NGU patients, and serotype 4 is also associated with asymptomatic pyuria.UU can cause some NGUs (10%~30%). However, UU is often detected in the urethra of people without urethritis, and it is assumed that only certain serotypes are responsible. Patients may be new to the organism or may have a precipitating factor, such as mucosal immunodeficiency. Urethritis due to UU can be subclinical and self-limited. Another type of mycoplasma isolated from the human reproductive tract is MG, and some chlamydia-negative and UU-negative patients may be pathologically affected by this mycoplasma, especially in some cases of NGU that do not heal for a long time. It is believed that Mycoplasma hominis is associated with ovarian abscesses, salpingitis, abscesses, hemorrhagic onescystitisThere is a close relationship. UU can also causeprostatitis、epididymitisand infertility, urinary tract stones, pyelonephritis, etc. Clinically, it is not uncommon for MH and UU to cause infections outside the genitals, and MH sepsis has been found in patients who have developed after kidney transplantation, trauma, and genitourinary instrumentation.

After understanding the cause of Mycoplasma uroplasma infection, we can prevent the emergence of Mycoplasma uroplasma infection to a certain extent.If we are unfortunate enough to suffer from Mycoplasma uroplasma infection, we should not panic at first, and we should go to the hospital for treatment in time. In this way, we can more effectively avoid patients from being harmed. Finally, I wish people suffering from Mycoplasma uroplasma infection a speedy recovery and a happy life!