What are the factors for the development of gallstones?
We may all know that gallstones are a relatively high-incidence disease, many times when gallstones are painful, patients can not bear it, and many patients with gallstones do not know what are the factors of gallstones, in order to help you better understand the factors of gallstones, let's take a look at what are the factors of gallstones?
What are the factors for the development of gallstones?
Irreversible factors:
Age: The incidence of gallstones increases with age.
If the disease occurs in childhood, it is usually associated with hemolysis or congenital biliary disease. The peak age of onset is 40~50 years old.
Gender differences: clinical studies have shown that the incidence ratio of men to women is about 1:2, and the high incidence of cholesterol stones in women may be related to estrogen can increase cholesterol secretion in bile, reduce the amount and activity of total bile acids, and progesterone affects gallbladder contraction and causes cholestasis.
Genes and genetics: The incidence of gallstones varies significantly among ethnic groups, suggesting that genetic factors are one of the pathogenesis of gallstone disease.
Reversible factors:
Pregnancy: During pregnancy, the maternal estrogen increases, which changes the bile composition and increases the saturation of cholesterol; Slow emptying of the gallbladder during pregnancy; Maternal weight gain and dietary habits can also affect bile composition, alter the enterohepatic circulation of bile acids, and promote the formation of cholesterol crystals. Pregnancy promotes the formation of gallstones, and the number of pregnancies is positively correlated with the incidence of gallstones.
Obesity: Obesity is an important risk factor for the development of gallbladder cholesterol stones, and the incidence rate in obese people is 3 times that of normal weight people.
Diet: Dietary habits are the main factors affecting the formation of gallstones, and those who eat low-fiber and high-calorie foods will have a significantly higher degree of bile cholesterol and a significantly higher incidence of gallstones. In recent years, the incidence of gallstones in China has accounted for the main position of gallstones, and cholesterol stones are the main ones.
It is hoped that patients with gallstones should be examined and treated in the early stage to avoid aggravation of gallstones in the later stage, resulting in untreatable conditions, and finally wish the majority of gallstone patients a speedy recovery.