Uterine diseases plague 8 types of people To prevent endometrial cancer, endocrine regulation is required
Nowadays, many women are plagued by uterine diseases, so what kind of women are most likely to be troubled by uterine diseases? So in response to everyone's questions, today our editor will give you a brief introduction, and then let's listen to the editor's brief introduction to this issue!
1. Infertility
Risk factors for endometrial cancer, along with:parturitionThe more times it happens, the less dangerous it is.
Infertility caused by prolonged anovulation is more likely to occur than women who have given birth to one child. People with polycystic ovary syndrome are also susceptible to the disease for the same reason.
2. Obese people
Obesity is a manifestation of endocrine imbalance, a large amount of fat in the body increases the storage of estrogen, fat is also conducive to androgen alienation, increasing the amount of estrogen in the blood, leading to endometrial hyperplasia and even cancer.
3. Those with menstrual disorders, early age of menarche or delayed menopause
In the premenopausal period, it is often anovulated, and the endometrium is stimulated by a single estrogen without progesterone for a long time, resulting in hyperplastic changes.
4. Diabetes mellitus and hypertension
Some patients with diabetes and hypertension can develop polycystic ovary syndrome, endometrial atypical hyperplasia, and high estrogen levels in the body due to long-term pituitary abnormalities, which are also one of the causes of cancer.
5. Those who take exogenous estrogen for a long time for various reasons
Exogenous estrogen alone without progesterone counteraction can increase the risk of endometrial cancer, and is related to the dose and length of estrogen used, and the risk can be reduced if progestogen is added.
6. Uterine bleeding that cannot be cured for a long time
In particular, postmenopausal uterine bleeding should be considered as a possibility of endometrial cancer, and gynecological examination should be done as soon as possible for early detection and early treatment.
7. Those with a history of X-ray exposure
Due to the influence of genetic factors, patients with endometrial cancer often have a family history and a history of tumors in close relatives, so those with a family history of endometrial cancer and a history of tumors in close relatives have a higher risk of developing the disease.
8. People with high economic income and higher education
The risk of developing endometrial cancer is twice as high as that of poorer people, which may be related to excessive fat intake and less physical activity.
Regulate endocrine and prevent endometrial cancer
Uterine cancer refers to the cancerous transformation of the endometrium, so the correct name should be endometrial cancer, which is one of the common malignant tumors of the female reproductive system and one of the killers of women's health. It is more common in perimenopausal women over the age of 50. Endometrial cancer is an estrogen-dependent tumor, and its pathogenesis is inseparable from estrogen.
Women of childbearing age have vigorous ovarian function and a normal menstrual cycle. With the development of follicles in each cycle, the level of estrogen in the body gradually increases, and estrogen stimulates the endometrium to proliferate; After ovulation, the follicle forms the corpus luteum, which produces estrogen and progesterone.
Progesterone, also known as progesterone, can not only change the endometrium on the basis of hyperplasia, prepare for the implantation of the fertilized egg, but also have the effect of restricting the continued proliferation and growth of the endometrium, thereby preventing the uncontrolled growth of the endometrium like weeds. This characteristic of progesterone is of great significance in preventing the endometrium from becoming cancerous.
Women of childbearing age are in the stage of vigorous ovarian function, the endometrium periodically receives the effects of estrogen and progesterone, the endometrium first shows proliferative changes, and after ovulation receives the dual effects of estrogen and progesterone, there are secretory changes, which restricts the continued proliferation and thickening of the endometrium.
Due to the protection of progesterone, women of childbearing age usually do not develop endometrial cancer. Therefore, progesterone is the protector of the endometrium.
After the age of 40, especially after the age of 45, women gradually enter menopause, and the ovaries begin to gradually enter the stage of functional decline from the stage of vigorous function, which is specifically manifested in the gradual degeneration of the follicles in the ovaries and the gradual loss of ovulation ability.
The ovaries are no longer able to ovulate, which means that the ovaries no longer periodically appear corpus luteum and no longer produce progesterone. Dysfunctional uterine bleeding (known as leakage in traditional Chinese medicine) is a common occurrence in menopausal women due to the inability of the ovaries to ovulate and the lack of progesterone in the body, resulting in disordered endometrial hyperplasia.
Long-term stimulation of the endometrium by a single estrogen in menopausal women can promote the uncontrolled growth of the endometrium, which can cause dysfunctional uterine bleeding and endometrial cancer.
Therefore, regulating endocrine, preventing and treating dysfunctional uterine bleeding during menopause has the effect of preventing endometrial cancer.
The method of endocrine regulation is very simple, and the price is very low, the specific use method is to use progesterone cycle therapy: medroxyprogesterone (also known as progesterone) 6~10 mg (3~5 tablets), oral on the 15th day of the menstrual cycle, once a day, continuous 10 days, 3~7 days after menstruation.
Progesterone cycle therapy is to imitate the normal menstrual cycle, supplement progesterone in the second half of menstruation, so that the proliferative endometrium is transformed into a secretory endometrium, and inhibit the growth of the endometrium, so as to prevent endometrial cancer.
After menopause, the ovaries atrophy and fail, and they no longer secrete estrogen and progesterone. But in reality, postmenopausal elderly women are still favored by endometrial cancer, and endometrial cancer occurs from time to time.
There are three types of estrogen present in the body: estradiol (E2), estrone (E1), and estriol (E3).Estradiol is produced by the ovaries, about half of the estrone is produced by the ovaries, and the other half is mainly synthesized by tissues such as fat, and estriol is a metabolite of estradiol and estrone, and the biological activity is weak.
After menopause, ovarian failure, estrogen in the body is mainly estrone synthesized by fat and other tissues, therefore, obese people will synthesize more estrone from excess fat, and excess estrone stimulates the endometrium, which is easy to induce endometrial cancer.
It can be seen that sex hormone imbalance and relatively high estrone levels in menopausal women are important factors in the incidence of endometrial cancer. Therefore, menstrual disorders, especially dysfunctional uterine bleeding, and obese patients should pay close attention to endometrial cancer, and should go to the hospital regularly for serious examination and cooperate with doctors to actively treat endometrial cancer to prevent the occurrence of endometrial cancer.