The important role of Huaiqi yellow granules in immune regulation

Huaiqi Huang Granules is an extract fermented from the mycelium of Huaiqi ear, and is made of granules made of traditional Chinese medicine wolfberry and Huangjing, which has the effect of nourishing essence, nourishing liver and kidney, nourishing heart and lungs, and strengthening muscles and bones.The main active ingredient of Sophora japonica is rich in mycopolysaccharide (PS-T), which has been confirmed to significantly enhance the immune response of body cells and has the function of immune regulation.

Studies have found that Huaiqi Huang granules have immunomodulatory effects, which can reduce the incidence of re-respiratory tract infection in children with severe Mycoplasma pneumoniae pneumonia in a short period of time by increasing the levels of immunoglobulins IgA, IgG, and IgM in human serum, the percentage of CD4+ T lymphocytes in immune cells, and the ratio of CD4+/CD8+[1].

At the same time, as an adjuvant treatment, Huaiqi Huang granules combined with glucocorticoids can reduce the urine protein level of patients with early diabetic nephropathy by inhibiting the levels of inflammatory factors such as IL-1β, IL-6, TNF-α, TGF-β1, and NF-κB, thereby reducing oxidative stress. 【2】。

A meta-analysis showed that the efficacy of Huaiqihuang granules in the treatment of recurrent respiratory tract infections in children was generally better than that of conventional treatment, and it could improve various immune function indicators. 【3】。

Animal experiments have found that Huangqi can significantly reduce alveolar wall damage and airway inflammation in asthma rats, reduce the proportion of eosinophils, and significantly decrease the concentrations of IL-3, IL-4, IL-5 and IgE, and increase the concentrations of IL-10 and INF-γ, thereby correcting the Th1/Th2 imbalance and achieving the purpose of alleviating asthma attacks, which may be regulated by the T-bet and GATA-3 pathways [4].

In summary, Huaiqi Huang granules have received extensive attention and application in regulating immune function. The existing basic theoretical research has provided some theoretical basis for improving immune function. With the deepening of experimental research, especially the application of cell biology and molecular biology techniques, the mechanism of action of Huaiqi yellow granules will be further revealed.