Is the only way to rule out leukemia is to do bone piercing? Is there any other way?

Usually, the diagnosis of leukemia can be ruled out by bone marrow examination alone. Clinically, hematological tests, cytogenetic analysis, and molecular biology are often used to determine whether the disease is present.

1. Hematology test: including peripheral blood picture and differential count, erythrocyte sedimentation rate (ESR) determination, C-reactive protein (CRP) level determination, liver function and kidney function monitoring, etc.;

2. Cytogenetic analysis: mainly to observe the chromosomal karyotype of the patient, and combined with fluorescence in situ hybridization (FISH), to determine whether there is clonal abnormal proliferation.If the patient has obvious abnormalities, it is necessary to further improve the genetic mutation detection and other related examinations to confirm the diagnosis;

3. Molecular biology: mainly including PCR technology or next-generation sequencing technology, and flow cytometry is widely used in clinical practice. This can be used to determine if there is a mutation in a specific gene in tumor cells, which can help doctors better understand the progression and prognosis of the disease.

It can also be comprehensively evaluated according to the symptoms and other laboratory test results, such as fever, anemia and other symptoms, it can be considered as acute leukemia; Chronic myeloid leukemia is mainly manifested by an enlarged spleen. Therefore, it is recommended that people who suspect that they may have leukemia seek medical treatment in time to avoid delaying the best diagnosis and treatment.