High CD3+ and CD8 are more or less leukemia

CD3 and CD8 are markers of T lymphocytes, and in general, if CD3 and CD8 are mildly elevated, leukemia cannot be determined. Because there is a certain fluctuation range of T lymphocytes in normal human bodies, and when patients have acute leukemia, CD3 and CD8 may increase significantly.

1. Abnormal manifestations in non-leukemia situations

1. CD3: Generally, the CD3 value in the blood is detected clinically, mainly to determine whether the body has an infection and whether there is an immune system disease.If it is caused by a viral infection, it will cause an increase in CD3 values;

2. CD8: If the CD8 index is significantly higher than the normal value during the examination, it means that there may be some neoplastic diseases or autoimmune diseases in the body.

2. Abnormal manifestations in the case of leukemia

Leukemia is a malignant clonal disease of hematopoietic stem cells, which can be divided into two types: acute myeloid leukemia and acute lymphoblastic leukemia in clinical practice. Among them, the proportion of blasts and promyelocytes in the bone marrow of patients with acute myeloid leukemia will increase, which can be manifested as a mildly elevated state of CD3 and CD8. Acute lymphoblastic leukemia, on the other hand, can cause bone marrow suppression due to the infiltration of a large number of naïve lymphocytes, resulting in a decrease in peripheral blood trilineage, and can also manifest as mildly elevated CD3 and CD8.

It is not accurate to diagnose leukemia based solely on CD3 and CD8 indicators, and a comprehensive analysis is needed in combination with other relevant examination results. It is recommended that patients go to the hospital for treatment in time, complete bone marrow aspiration and other related examinations to clarify the cause and then treat the symptoms.