Causes of prostate cancer in men

Many readers are still very unfamiliar with prostate cancer, in fact, prostate cancer is a common male malignant tumor, which will bring great harm to patients. So, what are the causes of prostate cancer in men? The experts consulted by the editor, and the following are the answers of the experts.

1. Chromosomal variation. Chromosomal variations are more common in prostate cancer, and are manifested by heterotable deletion, allele loss, gene amplification, and chromosomal rearrangements.

2. Tumor genes and tumor suppressor genes. The occurrence and malignant progression of prostate cancer is caused by the accumulation of DNA damage caused by changes in specific DNA gene groups. DNA point mutations, local gene amplification, cellular RNA or protein overexpression, chromosomal translocations and gene rearrangements can activate or overlay oncogenes, inactivate tumor suppressor genes and cause carcinogenes.

3. DNA methylation. DNA methylation is an early manifestation of solid cancer, and prostate cancer is no exception. Methylation of glutamine-S-transferase genes, androgen receptor primer genes, etc., in prostate cancer cells increases tumor susceptibility of cells.

4. Age, family genetics and ethnicity are definitive risk factors for the disease.Fatty diet, hormones, vitamins, trace elements, and vasectomy are possible or potential risk factors.

5. The normal prostatic epithelium is in a balance of low-level cell proliferation and apoptosis, and there is no net growth. The cell renewal cycle is about 500 days and remains relatively stable, while the growth of prostate cancer depends on this balance in favor of cell proliferation.