Can chemotherapy prolong life with chemotherapy for endometrial cancer Analysis of endometrial cancer causes

What should women do if they have endometrial cancer? Presumably this is a question that everyone is concerned about and concerned about, so in response to everyone's questions, today our editor will briefly introduce to you, what are the methods for treating endometrial cancer? The first choice for the treatment of endometrial cancer is surgery, and in the face of surgery, radiotherapy and chemotherapy, many endometrial cancer patients will be confused, which method will be most beneficial to them? How can these treatments be combined to maximize the chances of recovery?

In principle, as long as the patient's physical condition can tolerate it, the patient should be treated with surgery as soon as possible, unless the patient has serious medical comorbidities and cannot tolerate surgery; Or it is at an advanced stage and surgical resection is difficult to perform.

First, surgery can remove the cancerous uterus and other lesions that may have metastasized, including the ovaries, fallopian tubes, and surrounding lymph nodes. Through surgery, the tumor can be directly eradicated to achieve cure, or the tumor can be reduced in size to facilitate the patient's prognosis. Second, surgery allows for the correct diagnosis and staging of the disease. Although the vast majority of patients with endometrial cancer have undergone segmental curettage, the error rate of pathological type and degree of differentiation between the diagnostic and posthysterectomy specimens is as high as 20%, and these indicators are directly related to further treatment and prognosis after surgery. Therefore, accurate clinical staging is the guarantee for the selection of appropriate treatment, otherwise it is very likely to lead to over- or under-treatment.

Endometrial cancer is sensitive to radiotherapy, so radiotherapy is the preferred adjuvant treatment after surgery. Controlled studies have shown that radiotherapy can reduce the local recurrence rate and improve the 5-year survival rate of well-differentiated patients with moderately differentiated endometrial cancer. If the patient is medically ill, cannot tolerate surgery, or is not willing to undergo surgery at all, then radiation therapy is the first choice.

Can chemotherapy after surgery for advanced endometrial cancer prolong life?

According to a report in the Journal of Clinical Oncology, the combination of doxorubicin and cisplatin after surgery in women with advanced endometrial cancer significantly reduced the recurrence rate and prolonged life.

Marcus E, Multicenter Gynecologic Oncology Group, East Carolina University, Greenville, North Carolina, USA. Dr. Randall and his colleagues compared recurrence rates and overall survival rates in 194 patients treated with doxorubicin and cisplatin for 5 months versus 202 patients treated with whole-abdominal radiotherapy for 1.5 months. These women had stage III or IV endometrial cancer with a maximum tumor residual of 2 cm after surgery. After 5 years, 55% of chemotherapy patients were shown to be alive, compared with 42% in the radiotherapy group. Disease freedom was 50% in the chemotherapy group and 38% in the radiotherapy group. The hazard ratios for death and disease progression were 0.68 and 0.71, respectively, and the chemotherapy group was superior to the radiotherapy group.

However, treatment-related side effects were more common and severe in the chemotherapy group, particularly in the hematologic, cardiac, and neurological aspects, where chemotherapy resulted in death in eight (4%) and radiation therapy in five (2%). Therefore, researchers are currently investigating whether carboplatinum and paclitaxel have the same efficacy as doxorubicin and cisplatin, but with fewer side effects.

Why do women have endometrial cancer?

Endometrial cancer is a malignant tumor that can easily endanger a woman's life, so why do women have endometrial cancer? In fact, there are many reasons why women can get endometrial cancer.The following editor will introduce to you why women have endometrial cancer?

Causes of endometrial cancer 1: High blood pressure

There are many patients with endometrial cancer and hypertension.

Obesity, diabetes, and hypertension coexist in patients with endometrial cancer, which is called "endometrial triad" or "endometrial cancer syndrome". The three may be related to a high-fat diet, which is directly related to endometrial cancer.

The second cause of endometrial cancer is early menarche and late menopause

The incidence of endometrial cancer is 60% higher before the age of 12 than in those with menarche after the age of 12. The age of mild endometrial cancer is 6 years later than in normal women.

Causes of endometrial cancer 3. Exogenous estrogen

Women who take estrogen have a high risk of developing endometrial cancer, and the risk is related to the size of the dose, the length of time it is taken, whether the progestogen is combined, whether the drug is discontinued in the middle, and the characteristics of the patient. After the discontinuation of the drug, the danger decreases in ash, but the danger continues for several years. Currently, there is ample evidence of a causal relationship between estrogen and endometrial cancer.

The fourth cause of endometrial cancer is obesity

Excess fat will increase estrogen stores, as well as increase the conversion of androstenedione to estrone in plasma. This increase in free active estrone may be a carcinogenic factor for endometrial cancer, or a cancer-promoting factor.

Causes of endometrial cancer 5. Menstrual disorders

Patients with endometrial cancer, menstrual disorders, and heavy menstruation are 3 times higher than those of normal women.

To sum up, the above is about why women have endometrial cancer? It can allow women to better understand the causes of endometrial cancer, women should stay away from these adverse factors, in order to better prevent endometrial cancer, and women should usually maintain local hygiene and do not eat spicy and irritating food.